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Rhodes, Christopher
One or more keywords matched the following items that are connected to Rhodes, Christopher
Item TypeName
Concept Diabetes Mellitus, Experimental
Concept Diabetes Mellitus, Type 1
Concept Diabetes Mellitus, Type 2
Concept Diabetes Mellitus
Academic Article Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.
Academic Article Insulin-secreting non-islet cells are resistant to autoimmune destruction.
Academic Article Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.
Academic Article Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
Academic Article A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
Academic Article Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.
Academic Article Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.
Academic Article Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
Academic Article Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.
Academic Article Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?
Academic Article Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
Academic Article A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis.
Academic Article Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set?
Academic Article Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
Academic Article A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.
Academic Article Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
Academic Article Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
Academic Article Type 2 diabetes-a matter of beta-cell life and death?
Academic Article Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.
Academic Article Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription.
Academic Article Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells.
Academic Article Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
Academic Article Beta-cell regeneration: epithelial mesenchymal transition pre-EMTpted by lineage tracing?
Academic Article Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
Academic Article Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.
Academic Article The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?
Academic Article Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
Academic Article Pancreatic regeneration in type 1 diabetes: dreams on a deserted islet?
Academic Article Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.
Academic Article Degradation of islet amyloid polypeptide by neprilysin.
Academic Article How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited.
Academic Article FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
Academic Article What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism.
Academic Article Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
Academic Article Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
Academic Article Long-term biochemical changes in the islets of Langerhans in mice following infection with encephalomyocarditis virus.
Academic Article Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.
Academic Article Molecular insights into insulin action and secretion.
Academic Article The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
Academic Article Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
Academic Article IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication.
Academic Article Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Academic Article Islet autoantigens: structure, function, localization, and regulation.
Academic Article Direct autocrine action of insulin on ß-cells: does it make physiological sense?
Academic Article ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Academic Article ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Academic Article Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.
Academic Article SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed ß cells.
Academic Article The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions.
Academic Article 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004.
Academic Article Free Fatty Acid-Induced Inhibition of Glucose and Insulin-Like Growth Factor I-Induced Deoxyribonucleic Acid Synthesis in the Pancreatic ß-Cell Line INS-1* * This work was supported by grants from the NIH (GK-55267), the Juvenile Diabetes Foundation International, the German Research Society, and BetaGene, Inc.
Academic Article Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
Academic Article Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
Academic Article The dynamic plasticity of insulin production in ß-cells.
Academic Article Pancreatic ß-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes.
Academic Article Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia.
Academic Article Targeting Vessel Formation in Pulmonary Arterial Hypertension: Is the Endostatin-Id1-Thrombospondin 1 Pathway a New Hope?
Academic Article Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
Academic Article Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis.
Academic Article Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
Academic Article Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.
Academic Article High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity.
Academic Article Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity.
Concept Human Genetics
Grant Mitogenic Signal Transduction in Pancreatic Beta-Cells
Grant Metabolic Control of Insulin Exocytosis
Grant Central Control of Pancreatic Islet Function
Grant Western Region Islet Study Group
Grant An Interdisciplinary Molecular Metabolism Training Program
Grant Metabolic Control of Proinsulin Biosynthesis Translation
Grant Metabolic Control of Proinsulin Biosynthesis Translation
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  • Genetics
  • diabetes